‘St. Denis Medical’ Season 2 Casts Adam Rippon, Paul Scheer, Wayne Knight, Jessica Lowe, Jared Goldstein (EXCLUSIVE)
Andre Martin | Last Updated : October 31, 2025The acclaimed mockumentary series, ‘St. Denis Medical’, is gearing up for its second season with a notable expansion to its guest star roster. Exclusive reports confirm that Olympic gold medalist Adam Rippon, alongside veteran comedic talents Paul Scheer and Wayne Knight, will be joining the cast. They are further accompanied by Jessica Lowe and Jared Goldstein, promising a fresh array of personalities to interact with the beleaguered staff of St. Denis Medical. These additions suggest an exciting evolution for the series, which is known for its humorous take on the day-to-day chaos of a hospital.
‘St. Denis Medical’ Season 2 Expands Its Ensemble
The second season of ‘St. Denis Medical’ is poised to introduce a diverse group of guest stars, bringing a blend of athletic charisma and established comedic prowess to the fictional medical facility. Adam Rippon, widely recognized for his Olympic figure skating achievements, steps into the world of scripted comedy. He is joined by Paul Scheer, known for his roles in series like “Black Monday” and “The League”, and Wayne Knight, whose extensive career includes memorable parts in “Seinfeld” and “Jurassic Park”. Jessica Lowe, from “Wrecked” and “Minx”, and Jared Goldstein, seen in “Dollface” and “The Unicorn”, round out this new quintet of guest appearances for the upcoming season.
Introducing the New Guest Star Roles
The newly announced cast members will portray a variety of characters, each set to bring unique dynamics and comedic situations to the St. Denis Medical environment:
- Adam Rippon will play a male patient. His character is tasked with the challenge of convincing Dr. Bruce of his ailments, likely leading to some humorous exchanges within the hospital setting.
- Paul Scheer takes on the role of Ruben, the brother of a patient awaiting a kidney transplant. Despite a contentious relationship with his sibling, Ruben reportedly works diligently with the St. Denis Medical doctors to facilitate his brother’s life-saving procedure.
- Wayne Knight is cast as Dr. Axler, a gruff cardiologist. Dr. Axler is depicted as frequently clashing with Ron, with tensions escalating when he critiques one of Ron’s medical decisions.
- Jessica Lowe portrays Violet, a cheerful yet somewhat eccentric woman. Her arrival at St. Denis is driven by a surprising goal: to win back her ex-husband, a quest that is expected to astound the hospital staff.
- Jared Goldstein will appear as a technician. This character is responsible for operating a new health screening machine at St. Denis, indicating potential storylines involving new medical technology and patient interactions.
Returning Favorites and Additional Guest Appearances
The upcoming season of ‘St. Denis Medical’ will see the return of its core ensemble, including Wendi McLendon-Covey, David Alan Grier, Allison Tolman, Josh Lawson, Kahyun Kim, Mekki Leeper, and Kaliko Kauahi, whose performances anchor the mockumentary’s distinct style. These new additions will also join a list of previously announced guest stars set to appear in Season 2. This includes Ariana Madix, Draymond Green, Kristen Schaal, Lauren Weedman, Frankie Quiñones, Lauren Lapkus, Tim Baltz, Jeremiah Brown, and Jonah Beckett, further enriching the show’s comedic landscape with a wide range of talent from various entertainment fields.
Season 2 Premise and Production Insights
The second season of ‘St. Denis Medical’ is set to premiere on November 3rd, with back-to-back episodes airing from 8-9 p.m. ET/PT on NBC. For those who prefer streaming, new episodes will be available the day after their broadcast premiere on Peacock.
The logline for Season 2 offers a glimpse into the narrative direction: “After receiving a large private donation, hospital administrator Joyce (McLendon-Covey) bites off more than she can chew while her employees navigate staff shortages, office conflicts, and their own personal lives.” This premise suggests an increase in both internal and external pressures on the hospital staff, providing ample material for the series’ signature observational humor and character-driven comedy.
The series was brought to life by creators Eric Ledgin and Justin Spitzer. Ledgin also serves as showrunner and executive producer. Spitzer, along with Simon Heuer, Ruben Fleischer, Bridget Kyle, and Vicky Luu, are also credited as executive producers. Universal Television is the studio behind the production, continuing its involvement with the mockumentary format.
Anticipating ‘St. Denis Medical’ Season 2
With its blend of familiar faces and fresh talent, ‘St. Denis Medical’ Season 2 is shaping up to be a compelling continuation of the medical mockumentary. The integration of Adam Rippon, Paul Scheer, Wayne Knight, Jessica Lowe, and Jared Goldstein into the hospital’s eccentric ecosystem is expected to introduce new storylines and comedic opportunities, building on the established foundation of the series. Fans can look forward to exploring further the challenges and triumphs of the St. Denis staff as they navigate complex professional and personal lives, all under the unique lens of a hospital struggling with its newfound funding and ongoing operational quirks.
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