Is Pulmonary Arterial Hypertension Risk Assessment Solved By Cell-Free DNA?

Nikki Attkisson | Last Updated : September 1, 2022

According to the recent milestone development of the National Institute of Health in California, a new blood test has been identified. The purpose of the test is to assess the gravity of the disease in patients with pulmonary arterial hypertension. It is considered to be a kind of rare lung disease. The disease can be cured in numerous ways and the most effective measure is subjective functional assessment. It basically involves invasive measurements for assessing organ damage. The increasing potency of organ damage can happen due to a wider scope of CfDNA generation inside the body. 

This concentration can be a kind of activity biomarker in patients with the disease. This particular kind of infection is usually undetected in the beginning. There is practically no way with the help which a symptom can be developed and identified by the individual at the beginning of diagnosis. That is why developing a treatment, and a methodology for identification in such a situation becomes essential to a great extent. 

Effects On The Body Of The Person Who Suffers

When analyzing the after-effects of this disease, it is essential to mention that all patients with this condition have blocked blood vessels. The lungs do not operate due to the destruction of the blood vessels, thereby causing high blood pressure throughout the organ. The symptoms can usually prove to be fatal. 

Is Pulmonary Arterial Hypertension Risk Assessment Solved By Cell-Free DNA?

That is why quick, and early detection of this health problem is essential in such a situation. Presently the PAH-specific blood test is utilized to detect the progression of the given disease. But this test has also appeared to be ineffective over time.

Decoding the cell-free DNA test

According to this scientist and the researchers, this cell-free DNA and plasma test is proving to be equally effective in detecting the cell test. Only with the help of this test and cfDNA concentrations can the patients observe the development of REVEAL risk. This effective detection of hypertension can determine the severity of the disease. According to the experts, the effective concentration of DNA and analysis with the existing plasma survival kit help understand the specific parts of the lungs which are affected due to this infection. 

This experiment has already been conducted on a group of 4000 patients. The previous test has consistently failed to record all these findings, but on the other hand, this novel test has proved to be an effective method with the help of which detection can become more accessible and faster. It is useful in the long run for better efficiency and effectiveness. It is indirectly helpful for going ahead with the second part of the research and ultimately developing the proper treatment to reduce the risk to life in this kind of infection.

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In 4000 people over-diagnosed with all these problems, around 75% can give correct results with the help of these DNA-based findings. This is a significant milestone achievement in this particular regard. An enhanced amount of funding is being developed to effectively establish correlation. 


It can be concluded that this is an effective tool with the help of which such chronic illness can be detected at a very early stage without developing the risk of fatality and transmission to other body organs. It is helpful over some time for an effective measurement mechanism. This analysis will be valid for the effective treatment of a deadly illness so that unwanted death in this particular capacity can be reduced. This is also beneficial for all the patients who do not have any other kind of treatment for the time being.


🔵National Library Of Medicine (n.d)Role of biomarkers in evaluation, treatment and clinical studies of pulmonary arterial hypertension (Available Online):

🔵Science Direct (n.d) Risk assessment in pulmonary arterial hypertension: Insights from the GRIPHON study (Available Online):

Nikki Attkisson

With over 15 years as a practicing journalist, Nikki Attkisson found herself at Powdersville Post now after working at several other publications. She is an award-winning journalist with an entrepreneurial spirit and worked as a journalist covering technology, innovation, environmental issues, politics, health etc. Nikki Attkisson has also worked on product development, content strategy, and editorial management for numerous media companies. She began her career at local news stations and worked as a reporter in national newspapers.

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